8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

Base Information

Chemical Name:8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide
CAS No.:1448184-52-8
Molecular Formula:C₂₉H₂₆N₄O₄S₂
Molecular Weight:558.682
Hs Code.:

Synonyms:8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

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Chemical Property of 8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

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Technology Process of 8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

There total 6 articles about 8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1374399-93-5
2-(benzylthio)-N-(3-methoxypropyl)-5-oxo-7-hydroxy-4,5-dihydrothieno[3,2-b]pyridine-3-carboxamide

: 100-52-7
benzaldehyde

: 109-77-3
malononitrile

: 1448184-52-8
8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

Guidance literature:: With triethylamine; In ethanol; for 0.5h; Reflux;
DOI:10.1016/j.tet.2013.09.025

Reference yield:

: 15029-45-5
2-cyano-N-(3-methoxy-propyl) acetamide

: 1448184-52-8
8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 0.33 h / 10 °C

2.1: ethanol; water / 1 h

2.2: 2.7 h / Reflux

3.1: ethanol; water / 0.02 h / Reflux

4.1: triethylamine / ethanol / 0.5 h / Reflux

With triethylamine; potassium hydroxide; In ethanol; water;
DOI:10.1016/j.tet.2013.09.025

Reference yield:

: C₈H₁₁N₂O₂S₂^(1-)*K⁽¹⁺⁾

: 1448184-52-8
8-amino-2-(benzylthio)-7-cyano-N-(3-methoxypropyl)-5-oxo-6-phenyl-4,6-dihydro-5H-pyrano[2,3-d]thieno[3,2-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 1 h

1.2: 2.7 h / Reflux

2.1: ethanol; water / 0.02 h / Reflux

3.1: triethylamine / ethanol / 0.5 h / Reflux

With triethylamine; In ethanol; water;
DOI:10.1016/j.tet.2013.09.025