4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
• CAS No.: 81153-44-8
• Molecular Formula: C₁₆H₁₄ClN₃O₂
• Molecular Weight: 315.759

Synonyms:4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Chemical Property of 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

There total 12 articles about 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-[(5-methyl-2-phenyl-2H-pyrazol-3-ylamino)methylene]malonic acid diethyl ester (110299-41-7) → 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (81153-44-8)

Guidance literature:

With trichlorophosphate; for 4h; Heating;

DOI:10.1139/v88-074

Reference yield:

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) → 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (81153-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 120 °C

2: POCl₃ / 120 °C

With trichlorophosphate; 1: Michael addition;

DOI:10.1248/cpb.52.1098

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → 4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (81153-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 120 °C

2: POCl₃ / 120 °C

With trichlorophosphate; 1: Michael addition;

DOI:10.1248/cpb.52.1098

upstream raw materials:

2-[(5-methyl-2-phenyl-2H-pyrazol-3-ylamino)methylene]malonic acid diethyl ester

1-Phenyl-3-methyl-5-aminopyrazole

diethyl 2-ethoxymethylenemalonate

ethyl 4-hydroxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Downstream raw materials:

4-Chloro-3-methyl-1-phenylpyrazolo<3,4-b>pyridine-5-carboxylic acid

8-Methyl-6-phenyl-1,2-dihydro-6H-dipyrazolo[3,4-b;3',4'-d]pyridin-3-one

1,8-Dimethyl-6-phenyl-1,2-dihydro-6H-dipyrazolo[3,4-b;3',4'-d]pyridin-3-one

2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine

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