2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine

Base Information

• Chemical Name: 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine
• CAS No.: 412334-64-6
• Molecular Formula: C₂₁H₁₄ClN₃OS
• Molecular Weight: 391.881
• Mol file: 412334-64-6.mol

Synonyms:2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine

Chemical Property of 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine

There total 1 articles about 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (81153-44-8) + (4-chlorophenyl)methanethiol (6258-66-8) → 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine (412334-64-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 6h;

DOI:10.1016/S0960-894X(01)00651-5

Reference yield: 57.0%

glutaric anhydride, (108-55-4) + 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine (412334-64-6) → LASSBio 341

Guidance literature:

2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine; With potassium carbonate; In acetone; at 20 ℃; for 0.333333h;

glutaric anhydride,; In acetone; for 5h;

DOI:10.1016/S0960-894X(01)00651-5

Reference yield: 50.0%

4-bromophenylacetic acid (13737-36-5) + 2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine (412334-64-6) → {4-[2-(4-chloro-phenyl)-8-methyl-6-phenyl-6H-1-thia-5,6,7-triaza-as-indacen-3-yloxymethyl]-phenyl}-acetic acid

Guidance literature:

2-(4'-chlorophenyl)-3-hydroxy-6-phenyl-8-methylpyrazolo[3,4-b]thieno[2,3-d]pyridine; With potassium carbonate; In acetone; at 20 ℃; for 0.333333h;

4-bromophenylacetic acid; In acetone; for 13h;

DOI:10.1016/S0960-894X(01)00651-5

upstream raw materials:

4-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

(4-chlorophenyl)methanethiol

Downstream raw materials:

5-[2-(4-chloro-phenyl)-8-methyl-6-phenyl-6H-1-thia-5,6,7-triaza-as-indacen-3-yloxy]-pentanoic acid methyl ester

6-[2-(4-chloro-phenyl)-8-methyl-6-phenyl-6H-1-thia-5,6,7-triaza-as-indacen-3-yloxy]-hexanoic acid methyl ester