(S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

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Chemical Name:(S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide
CAS No.:70515-30-9
Molecular Formula:C₂₀H₂₃N₇O₃
Molecular Weight:409.448
Hs Code.:

Synonyms:(S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

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Chemical Property of (S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

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Technology Process of (S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

There total 3 articles about (S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 73074-28-9
(S)-N-[(2S,5R)-5-(6-Amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionamide

: 70515-30-9
(S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: With 2-Mercaptobenzothiazole; In pyridine; ethanol; acetic acid; Ambient temperature;
DOI:10.1016/S0008-6215(00)83661-7

Reference yield:

: 47364-78-3
O-methyl-N-(o-nitrophenylsulfenyl)-L-tyrosine

: 70515-30-9
(S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature

2: 78 percent / dimethylformamide / Ambient temperature

3: 76 percent / 2-mercaptobenzothiazole / ethanol; pyridine; acetic acid / Ambient temperature

With 2-Mercaptobenzothiazole; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)83661-7

Reference yield:

: 73074-23-4
N-hydroxysuccinimide ester of O-methyl-N-(o-nitrophenylsulfenyl)-L-tyrosine

: 70515-30-9
(S)-2-Amino-N-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / dimethylformamide / Ambient temperature

2: 76 percent / 2-mercaptobenzothiazole / ethanol; pyridine; acetic acid / Ambient temperature

With 2-Mercaptobenzothiazole; In pyridine; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)83661-7