N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide

Base Information

• Chemical Name: N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide
• CAS No.: 678188-88-0
• Molecular Formula: C₃₃H₅₅N₅O₅
• Molecular Weight: 601.83

Synonyms:N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide

Chemical Property of N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide

There total 9 articles about N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate (145013-05-4) + N-(6-amino-hexyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide (678188-84-6) → C33H55N5O5 (678188-88-0)

Guidance literature:

With triethylamine; mercury dichloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2003.10.048

Reference yield: 57.0%

N-(2-aminohexyl)-N-(1-phenethylpiperidin-4-yl)propionamide trifluoroacetate salt + tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate (145013-05-4) → N-[6-(N2,N3-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide (678188-88-0)

Guidance literature:

With triethylamine; mercury dichloride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2006.06.007

Reference yield:

1,6-Hexanediamine (124-09-4) → N-[6-(N2,N3-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide (678188-88-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / CHCl₃ / 0 - 20 °C

2: 88 percent / NaBH₃CN; molecular sieves 3 Angstroem; AcOH / methanol / pH 6 - 7

3: 73 percent / 4-(dimethylamino)pyridine; pyridine / CH₂Cl₂ / 20 °C

4: 91 percent / CH₂Cl₂ / 0.5 h / 20 °C

5: 57 percent / Et₃N; HgCl₂ / CH₂Cl₂ / 3 h / 20 °C

With pyridine; dmap; 3 A molecular sieve; sodium cyanoborohydride; acetic acid; triethylamine; mercury dichloride; In methanol; dichloromethane; chloroform;

DOI:10.1016/j.bmc.2006.06.007

upstream raw materials:

tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

N-(6-amino-hexyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide

1,6-Hexanediamine

tert-butyl N-(6-aminohexyl)carbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 678188-88-0 N-[6-(N²,N³-bis(tert-butoxycarbonyl)guanidino)hexyl]-N-(1-phenethylpiperidin-4-yl)propanamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send