N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

Base Information

Chemical Name:N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea
CAS No.:1446941-70-3
Molecular Formula:C₃₆H₃₆N₄O₄S
Molecular Weight:620.772
Hs Code.:

Synonyms:N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

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Chemical Property of N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

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Technology Process of N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

There total 6 articles about N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1446941-54-3
N,N'-bis[(hydroxymethylpyridin-2-yl)methyl]thiourea

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1446941-70-3
N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 22h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.05.046

Reference yield:

: 150058-64-3
(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)methanol

: 1446941-70-3
N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide; triphenylphosphine; carbon tetrabromide; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 5 h / 0 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C

5: pyridine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

With pyridine; sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.05.046

Reference yield:

: 1311298-52-8
2-azidomethyl-6-tertbutyldimethylsilyloxymethylpyridine

: 1446941-70-3
N-{[3-(4,4'-dimethoxytrityloxymethyl)pyridin-2-yl]methyl}-N'-[(6-hydroxymethylpyridin-2-yl)methyl]thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 5 h / 0 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C

4: pyridine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.05.046