Technology Process of 5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4,4-difluoro-pentanoic acid
There total 8 articles about 5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4,4-difluoro-pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Zn / tetrahydrofuran / 0 - 20 °C / ultrasound
2: tetrahydrofuran / 3 h / 80 °C
3: 79 percent / triethylsilane; benzoyl peroxide / 3 h / Heating
4: 86 percent / NH3 / diethyl ether / 0.5 h / -78 °C
5: 98 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 0 deg C, 1 h, 20 deg C, 2 h
6: 70 percent / NaHCO3 / ethyl acetate / 0.5 h / 0 °C
7: 96 percent / toluenesulfonic acid / methanol / 6 h / 50 °C
8: 50 percent / pyridinium dichromate / dimethylformamide / 16 h / 20 °C
With
triethylsilane; dipyridinium dichromate; o-toluenesulfonic acid; ammonia; sodium hydrogencarbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; zinc; dibenzoyl peroxide;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
1: Condensation / 2: Acylation / 3: oxidative cleavage / 4: Hydrogenolysis / 5: Hydrogenation / 6: Acylation / 7: Hydrolysis / 8: Oxidation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 70 percent / NaHCO3 / ethyl acetate / 0.5 h / 0 °C
2: 96 percent / toluenesulfonic acid / methanol / 6 h / 50 °C
3: 50 percent / pyridinium dichromate / dimethylformamide / 16 h / 20 °C
With
dipyridinium dichromate; o-toluenesulfonic acid; sodium hydrogencarbonate;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;
1: Acylation / 2: Hydrolysis / 3: Oxidation;
