(2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

Base Information

Chemical Name:(2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine
CAS No.:1450620-98-0
Molecular Formula:C₁₉H₂₃F₃N₂O₂
Molecular Weight:368.399
Hs Code.:

Synonyms:(2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

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Chemical Property of (2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

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Technology Process of (2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

There total 12 articles about (2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-70-8
4-(4-bromophenyl)-2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolane

: 1450620-13-9
benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-98-0
(2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1450620-77-5
benzyl (3S)-4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-98-0
(2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: With trifluorormethanesulfonic acid; trifluoroacetic acid; at 20 ℃; for 1.5h;

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1450620-98-0
(2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / 6 h / 20 °C

3.1: toluene-4-sulfonic acid / 40 h / 20 °C

4.1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With osmium(VIII) oxide; n-butyllithium; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane;