3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

Base Information

Chemical Name:3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester
CAS No.:905569-02-0
Molecular Formula:C₂₁H₂₅BrN₂O₆S
Molecular Weight:513.409
Hs Code.:

3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid <i>tert</i>-butyl ester

Synonyms:3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

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Chemical Property of 3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

There total 2 articles about 3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 115-11-7,15220-85-6
isobutene

: (S)-2-(4-Bromo-benzenesulfonylamino)-succinamic acid

: 905569-02-0
3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

Guidance literature:: (S)-2-(4-Bromo-benzenesulfonylamino)-succinamic acid; With sodium hydroxide; bromine; at 0 - 85 ℃;

isobutene; With sulfuric acid;

benzyl chloroformate; With sodium hydrogencarbonate; In diethyl ether;
DOI:10.1021/jm049666k

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 905569-02-0
3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / tetrahydrofuran; H₂O / 20 °C

2.1: Br₂; aq. NaOH / 0 - 85 °C

2.2: H₂SO₄

2.3: aq. NaHCO₃ / diethyl ether

With sodium hydroxide; bromine; triethylamine; In tetrahydrofuran; water;
DOI:10.1021/jm049666k

Reference yield:

: 905569-02-0
3-benzyloxycarbonylamino-2-(4-bromo-benzenesulfonylamino)-propionic acid tert-butyl ester

: 801240-24-4
3-amino-2-(4-{3-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-propyl}-benzenesulfonylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)2Cl₂; CuI; Et₃N / various solvent(s)

2: H₂ / Pd/C / ethanol

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm049666k