(1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

Base Information

Chemical Name:(1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide
CAS No.:1438844-87-1
Molecular Formula:C₂₁H₃₂N₂O₃S
Molecular Weight:392.563
Hs Code.:

Synonyms:(1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

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Chemical Property of (1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

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Technology Process of (1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

There total 5 articles about (1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: C₁₇H₂₂ClNO₃S

: 109-89-7
diethylamine

: 1438844-87-1
(1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

Guidance literature:: In dichloromethane; for 8h; Reflux;
DOI:10.1016/j.tetasy.2013.04.003

Reference yield:

: 23978-82-7
(1S,5R)-6,6-dimethylbicyclo<3.1.1>hept-2-ene

: 1438844-87-1
(1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 168 h / 20 °C

2: water; hydrogenchloride / 2 h / 20 °C

3: triethylamine / dichloromethane / 24 h / 0 - 20 °C

4: thionyl chloride / toluene / 3 h / 60 °C

5: dichloromethane / 8 h / Reflux

With hydrogenchloride; thionyl chloride; water; triethylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2013.04.003

Reference yield:

: 1438844-86-0
(1R,2R,3S,5R)-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxylic acid

: 1438844-87-1
(1R,2R,3S,5R)-N,N-diethyl-6,6-dimethyl-2-(4-methylphenylsulfonamido)bicyclo[3.1.1]heptane-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 3 h / 60 °C

2: dichloromethane / 8 h / Reflux

With thionyl chloride; In dichloromethane; toluene;
DOI:10.1016/j.tetasy.2013.04.003