(3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

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Chemical Name:(3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester
CAS No.:190264-78-9
Molecular Formula:C₁₃H₂₀N₂O₃
Molecular Weight:252.313
Hs Code.:

Synonyms:(3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

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Chemical Property of (3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

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Technology Process of (3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

There total 2 articles about (3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 109-76-2,54018-94-9
Trimethylenediamine

: 190264-64-3
(3S,5R)-1-ethynyl-3-hydroxy-2-methyl-5-[(vinyloxy)carbonyloxy]-1-cyclohexene

: 190264-78-9
(3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 48h;
DOI:10.1021/jo970133b

Reference yield:

: 113375-51-2
(3S,5R)-1-ethynyl-3,5-dihydroxy-2-methylcyclohex-1-ene

: 190264-78-9
(3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / toluene / 4 h / 30 °C / Candida antarctica lipase SP 435L presence, other biologically active materials: Chromobacterium viscosum lipase, Pseudomonas cepacia lipase

2: 76 percent / tetrahydrofuran / 48 h / 60 °C

In tetrahydrofuran; toluene;
DOI:10.1021/jo970133b

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 190264-78-9
(3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester

: 796039-27-5
(3S,5R)-5-[N¹-[3-(N²-tert-butyloxycarbonylaminopropyl)carbamoyl]oxy]-3-[(tert-butyldimethylsilyl)oxy]-1-ethynyl-2-methylcyclohex-1-ene

Guidance literature:: tert-butyldimethylsilyl chloride; (3-Amino-propyl)-carbamic acid (1R,5S)-3-ethynyl-5-hydroxy-4-methyl-cyclohex-3-enyl ester; With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 12h;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In chloroform; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2004.07.042