Technology Process of (2R,3R)-3-(3-methoxyphenyl)-2-methylpent-4-enoyl chloride
There total 5 articles about (2R,3R)-3-(3-methoxyphenyl)-2-methylpent-4-enoyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride;
In
toluene;
at 90 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / toluene / -15 - 20 °C / Inert atmosphere
1.2: Cooling with ice
2.1: carbon tetrabromide / 10 h / 60 °C
3.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.83 h / -60 °C / Inert atmosphere
3.2: 0.17 h
3.3: Cooling with ice
4.1: ethanol; tert-butyl methyl ether / 10 °C / Resolution of racemate
5.1: hydrogenchloride / ethyl acetate; water / 0.25 h / 20 °C
6.1: thionyl chloride / toluene / 4 h / 90 °C
With
hydrogenchloride; thionyl chloride; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane;
carbon tetrabromide;
In
ethanol; tert-butyl methyl ether; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: carbon tetrabromide / 10 h / 60 °C
2.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.83 h / -60 °C / Inert atmosphere
2.2: 0.17 h
2.3: Cooling with ice
3.1: ethanol; tert-butyl methyl ether / 10 °C / Resolution of racemate
4.1: hydrogenchloride / ethyl acetate; water / 0.25 h / 20 °C
5.1: thionyl chloride / toluene / 4 h / 90 °C
With
hydrogenchloride; thionyl chloride; triethylamine; lithium hexamethyldisilazane;
carbon tetrabromide;
In
ethanol; tert-butyl methyl ether; water; ethyl acetate; toluene;
