N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Base Information

Chemical Name:N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide
CAS No.:1450643-46-5
Molecular Formula:C₂₉H₃₂FNO₃
Molecular Weight:461.576
Hs Code.:

Synonyms:N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

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Chemical Property of N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

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Technology Process of N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

There total 12 articles about N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1382723-19-4
N-(2-(3'-fluoro-5-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

: 4-(benzyloxy)cyclohexyl 4-methylbenzenesulfonate

: 1450643-46-5
N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: N-(2-(3'-fluoro-5-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-(benzyloxy)cyclohexyl 4-methylbenzenesulfonate; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 16h;
DOI:10.1016/j.ejmech.2017.10.038

Reference yield:

: 52085-14-0
4-benzoxy-salicylaldehyde

: 1450643-46-5
N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide

3: ammonium acetate

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h

5: triethylamine

6: hydrogen; palladium on activated charcoal / methanol

7: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 90 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ammonium acetate; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

Reference yield:

: 2976-80-9
4-(benzyloxy)cyclohexan-1-ol

: 1450643-46-5
N-(2-(5-((4-(benzyloxy)cyclohexyl)oxy)-3'-fluoro-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 90 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.5b00331