Technology Process of N-(2-(3'-fluoro-5-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide
There total 1 articles about N-(2-(3'-fluoro-5-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 0 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Sealed tube; Reflux
3: ammonium acetate / 50 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
5: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere
6: palladium 10% on activated carbon; hydrogen / methanol / 12 h
With
lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; ammonium acetate; hydrogen; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2: Suzuki coupling / 3: Henry reaction;
DOI:10.1021/jm300544c
- Guidance literature:
-
N-(2-(3'-fluoro-5-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide; 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
Molecular sieve;
Inert atmosphere;
With
silver trifluoromethanesulfonate;
In
dichloromethane;
Inert atmosphere;
- Guidance literature:
-
N-(2-(3'-fluoro-5-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide; C14H19FO9;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
Molecular sieve;
With
boron trifluoride diethyl etherate;
In
dichloromethane;
at 20 ℃;
for 16h;
Inert atmosphere;
