5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one

Base Information

• Chemical Name: 5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one
• CAS No.: 152450-64-1
• Molecular Formula: C₁₃H₈F₆N₂O
• Molecular Weight: 322.21

Synonyms:5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one

Chemical Property of 5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one

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Technology Process of 5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one

There total 2 articles about 5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-methyl-1-phenylpyrazolin-5(4H)-one (19735-89-8) + Hexafluoroacetone (684-16-2) → 5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one (152450-64-1)

Guidance literature:

3-methyl-1-phenylpyrazolin-5(4H)-one; Hexafluoroacetone; With pyridine; In benzene; at 20 ℃; for 1h;

With thionyl chloride; In benzene; for 1h;

DOI:10.1134/S1070363212100155

Reference yield: 76.0%

4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-3-methyl-1-phenylpyrazol-5-one (111862-42-1) → 5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one (152450-64-1)

Guidance literature:

With thionyl chloride; In benzene; Heating;

DOI:10.1007/BF00863375

Reference yield: 95.0%

5-methyl-2-phenyl-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]-2,4-dihydro-3Н-pyrazol-3-one (152450-64-1) + malononitrile (109-77-3) → 6-amino-3-methyl-4,4-bis(trifluoromethyl)1-1phenyl-5-cyano-1H,4H-pyrazolo<3,4-b>pyran

Guidance literature:

With triethylamine; In benzene; at 20 ℃; for 12h;

DOI:10.1007/BF00863375

upstream raw materials:

4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-3-methyl-1-phenylpyrazol-5-one

3-methyl-1-phenylpyrazolin-5(4H)-one

Hexafluoroacetone

Downstream raw materials:

4-(1-amino-1-trifluoromethyl-2,2,2-trifluoroethyl)-3-methyl-1-phenylpyrazol-5-one

N,N,3-trimethyl-1-phenyl-4,4-bis(trifluoromethyl)-1H,4H-pyrazolo[4,3-e][1,3]oxazin-6-amine

C₁₈H₁₆F₆N₄O₂

3'-methyl-1'-phenyl-3,3-bis(trifluoromethyl)-1',5'-dihydrospiro[bicyclo[2.2.1]heptane-2,4'-pyrazol]-5-en-5'-one

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