N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide
CAS No.:1394938-42-1
Molecular Formula:C₂₅H₁₉F₅N₄O₂S₂
Molecular Weight:566.575
Hs Code.:

Synonyms:N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Suppliers and Price of N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

There total 15 articles about N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 21987-29-1
4,4-difluoropiperidine

: 1394939-15-1
N-{3-[2-bromo-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

: 1394938-42-1
N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: In N,N-dimethyl acetamide; at 120 ℃; for 3h; Microwave irradiation;
DOI:10.1002/cmdc.201402424

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1394938-42-1
N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 13 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / ethylene glycol / 6 h / 120 °C / Inert atmosphere

4: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

5: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.25 h / 80 °C / Microwave irradiation

6: ethanol / 0.33 h / 60 °C / Microwave irradiation

7: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C

8: N,N-dimethyl-formamide / 16 h / 20 °C

9: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 1 h / 110 °C / Microwave irradiation

10: ethylenediamine / ethanol / 8 h / Reflux

11: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 8 h / 85 °C

12: trifluoroacetic acid / water / 6 h / 80 °C

13: N,N-dimethyl acetamide / 3 h / 120 °C / Microwave irradiation

With pyridine; hydrogenchloride; N-Bromosuccinimide; tert.-butylnitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; caesium carbonate; pyridinium hydrobromide perbromide; ethylenediamine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; ethylene glycol; N,N-dimethyl-formamide; acetonitrile; 3: |Heck Reaction / 9: |Suzuki Coupling / 11: |Sandmeyer Reaction;
DOI:10.1002/cmdc.201402424

Reference yield:

: 1394939-08-2
N-{3-[2-bromo-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

: 1394938-42-1
N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; water / 6 h / 80 °C

2: triethylamine / ISOPROPYLAMIDE / 3 h / 120 °C / Microwave irradiation

With water; triethylamine; trifluoroacetic acid; In ISOPROPYLAMIDE;