5-cyclobutyl-2-methoxypyridine

Base Information

• Chemical Name: 5-cyclobutyl-2-methoxypyridine
• CAS No.: 1063961-23-8
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 1063961-23-8.mol

Synonyms:5-cyclobutyl-2-methoxypyridine

Chemical Property of 5-cyclobutyl-2-methoxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyclobutyl-2-methoxypyridine

There total 3 articles about 5-cyclobutyl-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) + Bromocyclobutane (4399-47-7) → 5-cyclobutyl-2-methoxypyridine (1063961-23-8)

Guidance literature:

Bromocyclobutane; With magnesium; In tetrahydrofuran; for 16h; Inert atmosphere; Reflux;

With zinc dibromide; In tetrahydrofuran; at -78 - 20 ℃; for 18h; Inert atmosphere;

2-methoxy-5-bromopyridine; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; for 16h; Reflux; Inert atmosphere;

DOI:10.1016/j.chempr.2019.12.014

Reference yield: 45.0%

4-chloromethoxybenzene (623-12-1) + potassium cyclobutyltrifluoroboranuide (1065010-88-9) → 5-cyclobutyl-2-methoxypyridine (1063961-23-8)

Guidance literature:

With n-BuPAd₂; caesium carbonate; palladium diacetate; In water; toluene; at 100 ℃; for 24h;

DOI:10.1021/jo801269m

Reference yield: 24.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) + cyclobutyl boronic acid (849052-26-2) → 5-cyclobutyl-2-methoxypyridine (1063961-23-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; toluene; Inert atmosphere; Reflux;

upstream raw materials:

4-chloromethoxybenzene

potassium cyclobutyltrifluoroboranuide

2-methoxy-5-bromopyridine

cyclobutyl boronic acid

Downstream raw materials:

5-cyclobutylpyridin-2(1H)-one