(2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

Base Information

Chemical Name:(2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine
CAS No.:1601479-76-8
Molecular Formula:C₁₇H₂₂F₂N₂O₂
Molecular Weight:324.371
Hs Code.:

Synonyms:(2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

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Chemical Property of (2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

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Technology Process of (2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

There total 11 articles about (2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1601482-72-7
tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-yl)carbamate

: 1601479-76-8
(2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

Guidance literature:: With hydrogenchloride; In methanol; for 2h;

Reference yield:

: 951127-27-8
1-(2,5-difluorophenyl)-2-nitroethanone

: 1601479-76-8
(2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl acetamide / 4 h / 25 - 30 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C

3.1: hydrogenchloride; zinc / water; ethanol / 1 h / 0 °C

4.1: methanol / 15 h / 25 °C

5.1: sodium carbonate / water; acetonitrile / 2 h / 0 - 30 °C

6.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile; dichloromethane / 3 h / 25 °C

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h

7.2: 0.25 h / 25 °C

7.3: 3 h

8.1: hydrogenchloride / methanol / 2 h

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; ruthenium(III) chloride trihydrate; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; zinc; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

: trans-2-(2,5-difluorophenyl)-5-methylidene-3-nitrotetrahydro-2H-pyran

: 1601479-76-8
(2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; zinc / water; ethanol / 1 h / 0 °C

2.1: methanol / 15 h / 25 °C

3.1: sodium carbonate / water; acetonitrile / 2 h / 0 - 30 °C

4.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile; dichloromethane / 3 h / 25 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h

5.2: 0.25 h / 25 °C

5.3: 3 h

6.1: hydrogenchloride / methanol / 2 h

With hydrogenchloride; sodium periodate; ruthenium(III) chloride trihydrate; sodium carbonate; N-ethyl-N,N-diisopropylamine; zinc; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;