2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

Base Information

Chemical Name:2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid
CAS No.:1352836-36-2
Molecular Formula:C₂₈H₂₃BrN₄O₄
Molecular Weight:559.419
Hs Code.:

Synonyms:2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

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Chemical Property of 2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

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Technology Process of 2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

There total 11 articles about 2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352836-26-0
4-(3-amino-2-methylphenyl)-7-bromo-9H-pyrido[3,4-b]indole-1-carboxamide

: 4785-56-2
2-formyl-5-methoxy-benzoic acid

: 1352836-36-2
2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352836-36-2
2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

4.1: 22 h / 120 - 125 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 7 h / 0 - 20 °C

6.1: hydrogenchloride / toluene; 1,4-dioxane; tetrahydrofuran / 24 h / 20 °C / Molecular sieve

6.3: 16 h / 1250 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C

7.2: pH 5 - 6

8.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2 h / 20 °C

9.1: trimethylsilyl iodide / acetonitrile / 1.5 h / 0 - 20 °C

10.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; tetrahydrofuran / 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; trimethylsilyl iodide; ammonium acetate; water; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 71516-35-3
2-methyl-3-nitrobenzonitrile

: 1352836-36-2
2-((3-(7-bromo-1-carbamoyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

3.2: 0.5 h / 20 °C / Cooling with ice

4.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

5.1: 22 h / 120 - 125 °C

6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 7 h / 0 - 20 °C

7.1: hydrogenchloride / toluene; 1,4-dioxane; tetrahydrofuran / 24 h / 20 °C / Molecular sieve

7.3: 16 h / 1250 °C

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C

8.2: pH 5 - 6

9.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2 h / 20 °C

10.1: trimethylsilyl iodide / acetonitrile / 1.5 h / 0 - 20 °C

11.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; tetrahydrofuran / 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; trimethylsilyl iodide; ammonium acetate; water; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;