Technology Process of EMD 36928
There total 1 articles about EMD 36928 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
2: 6 n HCl
3: 96 percent / liquid HF
4: 98 percent / HBr, HOAc / Ambient temperature
With
hydrogenchloride; hydrogen fluoride; hydrogen bromide; acetic acid;
DOI:10.1016/S0040-4039(00)71180-4
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74213-32-4
(5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 8 steps
1: 75 percent / H2 / Pd/C / H2O; methanol
2: SOCl2
3: 85 percent / H2 / Pd / toluene
4: 82 percent / Pb(OAc)2 / tetrahydrofuran
5: NaH / dioxane
6: NaH / dimethylformamide
7: various solvent(s) / 1 h / 50 °C
8: 44 percent / NaH, O2 / tetrahydrofuran; dimethylformamide
With
thionyl chloride; hydrogen; oxygen; lead acetate; sodium hydride;
palladium on activated charcoal; palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)71180-4
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(5aR,6aR,7R,10aR)-7-[(Ethylsulfanyl-phenyl-methyl)-amino]-1,8,10a,11-tetrahydroxy-10,12-dioxo-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 75 percent / H2 / Pd/C / H2O; methanol
2: SOCl2
3: 85 percent / H2 / Pd / toluene
4: 82 percent / Pb(OAc)2 / tetrahydrofuran
5: NaH / dioxane
6: NaH / dimethylformamide
7: various solvent(s) / 1 h / 50 °C
8: 44 percent / NaH, O2 / tetrahydrofuran; dimethylformamide
With
thionyl chloride; hydrogen; oxygen; lead acetate; sodium hydride;
palladium on activated charcoal; palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)71180-4
