Technology Process of (5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
There total 16 articles about (5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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70098-60-1,70116-54-0,74243-77-9,74243-78-0
(5aR,6aS,7R)-1,8,11-Trihydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
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74213-32-4
(5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
- Guidance literature:
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With
oxygen; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)71180-4
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74213-32-4
(5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 12 steps
2: 6 n HCl
3: 96 percent / liquid HF
4: 98 percent / HBr, HOAc / Ambient temperature
5: 75 percent / H2 / Pd/C / H2O; methanol
6: SOCl2
7: 85 percent / H2 / Pd / toluene
8: 82 percent / Pb(OAc)2 / tetrahydrofuran
9: NaH / dioxane
10: NaH / dimethylformamide
11: various solvent(s) / 1 h / 50 °C
12: 44 percent / NaH, O2 / tetrahydrofuran; dimethylformamide
With
hydrogenchloride; thionyl chloride; hydrogen fluoride; hydrogen bromide; hydrogen; oxygen; lead acetate; sodium hydride; acetic acid;
palladium on activated charcoal; palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)71180-4
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74213-32-4
(5aR,6aR,7R,10aR)-1,8,10a,11-Tetrahydroxy-10,12-dioxo-7-thiobenzoylamino-6,6a,7,10,10a,12-hexahydro-5aH-5-thia-naphthacene-9-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 13 steps
1: 63 percent
3: 6 n HCl
4: 96 percent / liquid HF
5: 98 percent / HBr, HOAc / Ambient temperature
6: 75 percent / H2 / Pd/C / H2O; methanol
7: SOCl2
8: 85 percent / H2 / Pd / toluene
9: 82 percent / Pb(OAc)2 / tetrahydrofuran
10: NaH / dioxane
11: NaH / dimethylformamide
12: various solvent(s) / 1 h / 50 °C
13: 44 percent / NaH, O2 / tetrahydrofuran; dimethylformamide
With
hydrogenchloride; thionyl chloride; hydrogen fluoride; hydrogen bromide; hydrogen; oxygen; lead acetate; sodium hydride; acetic acid;
palladium on activated charcoal; palladium;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)71180-4
