2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Chemical Name:2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one
CAS No.:1448718-01-1
Molecular Formula:C₂₃H₂₂FN₅O
Molecular Weight:403.459
Hs Code.:

Synonyms:2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Chemical Property of 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

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Technology Process of 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

There total 5 articles about 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1448717-98-3
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-iodo-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 1765-93-1
4-fluoroboronic acid

: 1448718-01-1
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1448717-96-1
3-[(1-benzyl-4-methyl-pyrrolidine-3-carbonyl)-amino]-3H-imidazole-4-carboxylic acid methyl ester

: 1448718-01-1
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; ammonium hydroxide / methanol / 48 h / 130 °C / Sealed tube

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -45 °C

2.2: 2 h / -78 - 0 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 18 h / 100 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; potassium carbonate; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 885958-71-4
(3RS,4RS)-1-benzyl-4-methyl-pyrrolidine-3-carboxylic acid

: 1448718-01-1
2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(4-fluoro-phenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 4 h / 85 °C / Reflux

2.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

3.1: ammonium acetate; ammonium hydroxide / methanol / 48 h / 130 °C / Sealed tube

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -45 °C

4.2: 2 h / -78 - 0 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 18 h / 100 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; ammonium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;