1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

Base Information

Chemical Name:1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene
CAS No.:1356486-35-5
Molecular Formula:C₁₆H₉F₃O
Molecular Weight:274.242
Hs Code.:

Synonyms:1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

Suppliers and Price of 1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

There total 2 articles about 1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 119754-17-5
(4-ethynylphenyl)(phenyl)methanone

: 1356486-35-5
1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

Guidance literature:: (trifluoromethyl)trimethylsilane; With 1,10-Phenanthroline; potassium tert-butylate; silver carbonate; copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Molecular sieve; Inert atmosphere;

(4-ethynylphenyl)(phenyl)methanone; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1002/ejoc.201101550

Reference yield:

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 1356486-35-5
1-((4-benzoyl)phenyl)-2-(trifluoromethyl)acetylene

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 h / 50 °C / Schlenk technique; Inert atmosphere

1.2: 1 h / 20 °C

2.1: copper(l) iodide; potassium carbonate; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 24.5 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201400057