(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate
CAS No.:916793-76-5
Molecular Formula:C₃₅H₅₉N₃O₈
Molecular Weight:649.869
Hs Code.:

(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

Synonyms:(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

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Chemical Property of (2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

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MSDS Files:: SDS file from LookChem

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Technology Process of (2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

There total 7 articles about (2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 24424-99-5
di-tert-butyl dicarbonate

: C₃₀H₅₁N₃O₆

: 916793-76-5
(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo5015195

Reference yield:

: 916793-75-4
(2R,3S,5S)-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-isopropyl-2-[4-methoxy-3-(3-methoxypropoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 324763-51-1
aminopivalinamide

: 916793-76-5
(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: With 2-hydroxypyridin; triethylamine; In tert-butyl methyl ether; at 83 ℃; for 18h;

Reference yield:

: (3S,8S,9R)-3,8-diisopropyl-9-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-4,7,8,9-tetrahydro-3H-oxonin-2-one

: 916793-76-5
(2R,3S,5S)-tert-butyl 5-((1S,3S)-3-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium oxide; Rh₂(tfacam)₄; [bis(acetoxy)iodo]benzene / toluene / 16 h / 0 - 25 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: triethylamine; 2-hydroxypyridin / 72 h / 85 °C / Inert atmosphere

4.1: acetic acid; zinc copper / methanol / 16 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: potassium carbonate; tetrabutylammomium bromide / dichloromethane; water / 16 h / 0 - 20 °C / Inert atmosphere

With 2-hydroxypyridin; zinc copper; [bis(acetoxy)iodo]benzene; Rh₂(tfacam)₄; tetrabutylammomium bromide; magnesium oxide; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; toluene;
DOI:10.1021/jo5015195