N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline

Base Information

• Chemical Name: N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline
• CAS No.: 219518-89-5
• Molecular Formula: C₂₀H₂₃N₃O₄Si
• Molecular Weight: 397.506
• Mol file: 219518-89-5.mol

Synonyms:N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline

Chemical Property of N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline

There total 3 articles about N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-cyanobenzoyl chloride (1711-11-1) + 4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline (215656-99-8) → N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline (219518-89-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm9903287

Reference yield:

4-hydroxy-2-nitroaniline (610-81-1) → N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline (219518-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 5 h

2: 94 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide; 1: Silylation / 2: Acylation;

DOI:10.1021/jm9903287

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N-(3-cyanobenzoyl)-2-nitro-4-(tert-butyldimethylsilyloxy)aniline (219518-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 5 h

2: 94 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide; 1: Silylation / 2: Acylation;

DOI:10.1021/jm9903287

upstream raw materials:

3-cyanobenzoyl chloride

4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline

4-hydroxy-2-nitroaniline

tert-butyldimethylsilyl chloride

Downstream raw materials:

N₁-(3-cyanobenzoyl)-4-(dimethyl-t-butylsiloxy)-1,2-benzenediamine

N¹-(3-cyanobenzoyl)-N²-(4-isopropylbenzoyl)-4-hydroxy-1,2-benzenediamine

N¹-(3-(amino(hydroxyimino)methyl)benzoyl)-N²-(4-iso-propylbenzoyl)-4-hydroxy-1,2-benzenediamine

N¹-(3-cyanobenzoyl)-N²-(4-isopropylbenzoyl)-4-(tert-butyldimethylsilyloxy)-1,2-benzenediamine