α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

Base Information

Chemical Name:α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol
CAS No.:116515-66-3
Molecular Formula:C₂₀H₂₄O₇
Molecular Weight:376.406
Hs Code.:

Synonyms:α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

Chemical Property:

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Technology Process of α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

There total 3 articles about α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103477-58-3
2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 116515-66-3
α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1) ether, THF, -78 deg C, 15 min, 2) THF, -78 deg C, 30 min;

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 116515-66-3
α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pTsOH*5H₂O / benzene / 3 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) -78 deg C, 30 min, rt, 2.5 h

With n-butyllithium; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jo952048e

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 116515-66-3
α-2-<(1,3-dioxolan-2-yl)-4,5-dimethoxyphenyl>-3,4-dimethoxybenzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / water; benzene / Reflux; Dean-Stark

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; water; benzene;
DOI:10.1007/s00044-012-0245-1