Technology Process of 6-Chloromelatonin
There total 9 articles about 6-Chloromelatonin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 89 percent / NaNO2, HNO3
2: 75 percent
3: dimethylformamide / 6 h / 130 °C
4: H2 / Raney-Ni / 2896.03 Torr
5: diethyl ether / 0.5 h / 0 °C
6: NH3 / toluene
7: 1.) (CH3)2S*BH3, 2.) aq. HCl / 1.) THF, reflux, 30 min, 2.) 100 deg C, 20 min
8: pyridine / ethyl acetate / Ambient temperature
With
pyridine; hydrogenchloride; dimethylsulfide borane complex; ammonia; hydrogen; nitric acid; sodium nitrite;
nickel;
In
diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 75 percent
2: dimethylformamide / 6 h / 130 °C
3: H2 / Raney-Ni / 2896.03 Torr
4: diethyl ether / 0.5 h / 0 °C
5: NH3 / toluene
6: 1.) (CH3)2S*BH3, 2.) aq. HCl / 1.) THF, reflux, 30 min, 2.) 100 deg C, 20 min
7: pyridine / ethyl acetate / Ambient temperature
With
pyridine; hydrogenchloride; dimethylsulfide borane complex; ammonia; hydrogen;
nickel;
In
diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dimethylformamide / 6 h / 130 °C
2: H2 / Raney-Ni / 2896.03 Torr
3: diethyl ether / 0.5 h / 0 °C
4: NH3 / toluene
5: 1.) (CH3)2S*BH3, 2.) aq. HCl / 1.) THF, reflux, 30 min, 2.) 100 deg C, 20 min
6: pyridine / ethyl acetate / Ambient temperature
With
pyridine; hydrogenchloride; dimethylsulfide borane complex; ammonia; hydrogen;
nickel;
In
diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
