62492-45-9

Basic information

• Product Name: 1-Chloro-2-methoxy-4-methyl-5-nitrobenzene
• Synonyms: 1-Chloro-2-methoxy-4-methyl-5-nitrobenzene;2-Chloro-5-methyl-4-nitroanisole
• CAS NO: 62492-45-9
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.60702
• Mol File: 62492-45-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 303.4°C at 760 mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 0.00168mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-Chloro-2-methoxy-4-methyl-5-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2-methoxy-4-methyl-5-nitrobenzene(62492-45-9)
• EPA Substance Registry System: 1-Chloro-2-methoxy-4-methyl-5-nitrobenzene(62492-45-9)

Safety Data

• Hazardous Substances Data: 62492-45-9(Hazardous Substances Data)

Usage

Uses

2-Chloro-5-methyl-4-nitroanisole, is used as a reactant or a reagent in various stereoselective synthesis.

InChI:InChI=1/C8H8ClNO3/c1-5-3-8(13-2)6(9)4-7(5)10(11)12/h3-4H,1-2H3

Upstream product

• 62509-09-5 2-chloro-5-methyl-4-nitroso-phenol 
• 615-74-7 2-chloro-5-methylphenol 
• 259860-00-9 2-fluoro-4-methyl-5-nitro-phenylamine 
• 452-80-2 2-fluoro-4-methylaniline 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 118664-99-6 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 
• 866996-99-8 1-chloro-4-methyl-2,5-dinitro-benzene 
• 7664-41-7 ammonia 
• 40130-97-0 2-chloro-5-methyl-4-nitro-phenol 
• 77-78-1 dimethyl sulfate 
• 124-41-4 sodium methylate 
• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 67-56-1 methanol 

Downstream Products

• 63762-72-1 6-chloro-5-methoxy-1H-indole 
• 63762-73-2 (6-chloro-5-methoxy-indol-3-yl)-acetonitrile 
• 1203844-49-8 C₁₃H₁₅ClN₂O₃ 
• 63762-74-3 N-[2-(6-chloro-5-methoxy-indol-3-yl)-ethyl]-acetamide 
• 62492-46-0 5-chloro-4-methoxy-2-methylaniline 
• 99474-19-8 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene 
• 63762-71-0 2-chloro-5-<(β-dimethylamino)-vinyl>-4-nitroanisole 

Relevant articles and documents

KINASE INHIBITORS AND METHODS OF USE

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

Melatonin derivatives - I - Synthesis of N-succinyl-6-chloro-5-methoxytryptamine

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Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues

A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.