(S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Base Information

• Chemical Name: (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate
• CAS No.: 1598386-65-2
• Molecular Formula: C₂₇H₃₅N₃O₄
• Molecular Weight: 465.593
• Mol file: 1598386-65-2.mol

Synonyms:(S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Chemical Property of (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

There total 2 articles about (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate (1597574-90-7) → (R)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate (1598386-64-1) + (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate (1598386-65-2)

Guidance literature:

With Chiralcel OD-H; Resolution of racemate;

Reference yield:

tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate (1597574-89-4) → (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate (1598386-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 2 h

2: Chiralcel OD-H / Resolution of racemate

With methanol; sodium tetrahydroborate;

Reference yield: 92.0%

7-(tert-butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid (873924-12-0) + (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate (1598386-65-2) → (S)-tert-butyl 2-(1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-5-(4-methoxypiperidin-1-yl)-1,2,3 ,4-tetrahydroisoquinoline-2-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate (1598386-66-3)

Guidance literature:

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 0 - 20 ℃;

upstream raw materials:

tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate

Downstream raw materials:

(S)-tert-butyl 2-(1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-5-(4-methoxypiperidin-1-yl)-1,2,3 ,4-tetrahydroisoquinoline-2-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate