1597574-89-4

Upstream product

• 18144-47-3 tert-butyl 4-aminobenzoate 
• 477721-50-9 tert-butyl 4-formamidobenzoate 
• 1224444-35-2 tert-butyl 4-isocyanobenzoate 
• 1597574-31-6 5-(4-methoxypiperidin-1-yl)-3,4-dihydroisoquinoline 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1597574-90-7 tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate 
• 1598386-64-1 (R)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate 
• 1598386-65-2 (S)-tert-butyl 4-(5-(4-methoxypiperidin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate 
• 1598386-66-3 (S)-tert-butyl 2-(1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-5-(4-methoxypiperidin-1-yl)-1,2,3 ,4-tetrahydroisoquinoline-2-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate 

Relevant academic research and scientific papers

TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

GUANIDINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be us

GUANIDINE AND AMINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): (Formula (I)) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.