diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate
CAS No.:137793-46-5
Molecular Formula:C₂₉H₄₀N₄O₈
Molecular Weight:572.659
Hs Code.:

Synonyms:diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

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Chemical Property of diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

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Technology Process of diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

There total 4 articles about diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 137793-45-4
diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butynyl>benzoyl>-L-glutamate

: 137793-46-5
diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1021/jm00084a016

Reference yield:

: 117500-15-9
ethyl 2-(ethoxycarbonyl)-5-hexynoate

: 137793-46-5
diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / NaOH/MeOH

2: 75 percent / pyridine / 8 h / 140 °C

3: 36 percent / PdCl₂, Ph₃P, CuI / acetonitrile / 12 h / Heating

4: 50 percent / H₂ / 5percent Pd/C / methanol / 760 Torr

With pyridine; methanol; sodium hydroxide; copper(l) iodide; hydrogen; triphenylphosphine; palladium dichloride; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00084a016

Reference yield:

: 137793-43-2
2-amino-1,6-dihydro-4-hydroxy-6-oxo-5-(3-butynyl)pyrimidine

: 137793-46-5
diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / pyridine / 8 h / 140 °C

2: 36 percent / PdCl₂, Ph₃P, CuI / acetonitrile / 12 h / Heating

3: 50 percent / H₂ / 5percent Pd/C / methanol / 760 Torr

With pyridine; copper(l) iodide; hydrogen; triphenylphosphine; palladium dichloride; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00084a016