117500-15-9

Basic information

• Product Name: Diethyl 2-(but-3-ynyl)Malonate
• Synonyms: Diethyl 2-(but-3-ynyl)Malonate;3-Butynylmalonic acid diethyl ester;3-Butynylpropanedioic acid diethyl ester;diethyl 2-(but-3-yn-1-yl)Malonate;1,3-DIETHYL 2-(BUT-3-YN-1-YL)PROPANEDIOATE;diethyl 2-but-3-ynylpropanedioate
• CAS NO: 117500-15-9
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.24234
• Mol File: 117500-15-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 128-130℃ (11 Torr)
• Flash Point: 128.0±23.0 oC
• Appearance: /
• Density: 1.054±0.06 g/cm3 (20 oC 760 Torr)
• Refractive Index: 1.4428 (589.3 nm 15℃)
• Storage Temp.: 2-8°C
• PKA: 12.34±0.59(Predicted)
• CAS DataBase Reference: Diethyl 2-(but-3-ynyl)Malonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl 2-(but-3-ynyl)Malonate(117500-15-9)
• EPA Substance Registry System: Diethyl 2-(but-3-ynyl)Malonate(117500-15-9)

Safety Data

• Hazardous Substances Data: 117500-15-9(Hazardous Substances Data)

Usage

General Description

Diethyl 2-(but-3-ynyl)Malonate is a chemical compound primarily used in organic synthesis and research. Its molecular formula is C11H16O4, and it appears as a clear liquid. There are limited studies available on its safety and environmental impact, so proper precautions should be taken when handling or storing this chemical. It's often utilized in the production of other chemical substances due to its ability to participate in diverse chemical reactions. As a niche scientific and industrial reagent, it is not typically encountered outside of a professional setting.

Upstream product

• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 
• 105-53-3 diethyl malonate 
• 5332-06-9 4-bromobutanenitrile 
• 38771-21-0 4-bromobut-1-yne 
• 43001-25-8 4-iodobut-1-yne 
• 996-82-7 sodium diethylmalonate 
• 1289154-34-2 ethyl 2,2-diethoxycarbonylhex-5-ynoate 

Downstream Products

• 1320359-55-4 ethyl 6-methylene-2-oxo-3-(2-(phenylsulfonyl)ethyl)tetrahydro-2H-pyran-3-carboxylate 
• 125162-81-4 6-amino-1-hydroxy-2-(hydroxymethyl)hexane 
• 137793-47-6 N-<4-<4-(1,6-dihydro-4-hydroxy-6-oxo-2-amino-5-pyrimidinyl)butyl>benzoyl>-L-glutamic acid 
• 137793-45-4 diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butynyl>benzoyl>-L-glutamate 
• 137793-46-5 diethyl N-<4-<4-<1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)-5-pyrimidinyl>butyl>benzoyl>-L-glutamate 
• 137793-44-3 5-(3-butynyl)-1,6-dihydro-4-hydroxy-6-oxo-2-(pivaloylamino)pyrimidine 
• 872791-03-2 2-(3-butyn-1-yl)malonate 

Relevant articles and documents

Synthesis method of ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol

The invention belongs to the technical field of medical intermediates, and concretely relates to a synthesis method of ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol. Diethyl malonate and 4-bromobutyronitrile adopted as starting raw materials are subjected toa substitution reaction, a reduction reaction, an FMOC protection and a DMT protection sequentially to synthesize the ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol. The product synthesized by the synthesis route has characteristics of high purity, high yield and easy operation, and the excellent route is provided for the synthesis of the ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol.

CoCl(PPh3)3 as Cyclotrimerization Catalyst for Functionalized Triynes under Mild Conditions

The ubiquitary Co(I) complex CoCl(PPh3)3 was found to be a convenient catalyst for the [2 + 2 + 2] cycloaddition of functionalized triynes under mild reaction conditions and devoid of any additional additive, yielding the substituted

Tandem cyclization-Michael reaction by combination of metal- and organocatalysis

The use of a catalytic amount of platinum complexes (1 mol%) was found to be compatible with different organocatalysts (DABCO or the Jorgensen- Hayashi catalyst) that were used in the functionalization of various activated methylenes. By this method, a series of lactones with C-3 quaternary centers and substitution at C-5 were prepared.