1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

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Chemical Name:1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene
CAS No.:945265-69-0
Molecular Formula:C₃₂H₄₈O₃Si₂
Molecular Weight:536.902
Hs Code.:

Synonyms:1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

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Chemical Property of 1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

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Technology Process of 1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

There total 10 articles about 1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (5R,6S)-3-(dimethylphenylsilanyl)-5-(4-methoxybenzyloxy)-6-methylnon-1-en-8-yn-4-ol

: 994-30-9
triethylsilyl chloride

: 945265-69-0
1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 45 ℃;
DOI:10.1016/j.tet.2007.02.058

Reference yield:

: C₂₀H₃₀O₄

: 945265-69-0
1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 9-BBN / tetrahydrofuran / Heating

1.2: 99 percent / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 20 °C

2.1: 99 percent / SO₃*pyridine; DMSO; i-Pr₂NEt / CH₂Cl₂ / 0 °C

3.1: Ph₃P / CH₂Cl₂ / cooling

4.1: 9.6 g / n-BuLi / tetrahydrofuran; hexane / -78 °C

5.1: 93 percent / AcOH / H₂O / 40 °C

6.1: 81 percent / NaIO₄; buffer / tetrahydrofuran / pH 7 / cooling

7.1: 90 percent / molecular sieves 4 Angstroem / toluene / -78 °C

8.1: 89 percent / imidazole / dimethylformamide / 45 °C

With 1H-imidazole; sodium periodate; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; pyridine-SO₃ complex; 4 A molecular sieve; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2007.02.058

Reference yield:

: 1-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-2-methylbut-3-en-1-ol

: 945265-69-0
1-[(1R,2S,3R)-3-(dimethylphenylsilanyl)-1-((S)-1-methylbut-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxybenzene

Guidance literature:: Multi-step reaction with 9 steps

1.1: 99 percent / NaH; NaI / tetrahydrofuran / Heating

2.1: 9-BBN / tetrahydrofuran / Heating

2.2: 99 percent / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 20 °C

3.1: 99 percent / SO₃*pyridine; DMSO; i-Pr₂NEt / CH₂Cl₂ / 0 °C

4.1: Ph₃P / CH₂Cl₂ / cooling

5.1: 9.6 g / n-BuLi / tetrahydrofuran; hexane / -78 °C

6.1: 93 percent / AcOH / H₂O / 40 °C

7.1: 81 percent / NaIO₄; buffer / tetrahydrofuran / pH 7 / cooling

8.1: 90 percent / molecular sieves 4 Angstroem / toluene / -78 °C

9.1: 89 percent / imidazole / dimethylformamide / 45 °C

With 1H-imidazole; sodium periodate; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; pyridine-SO₃ complex; 4 A molecular sieve; sodium hydride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2007.02.058