(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid

Base Information

• Chemical Name: (2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid
• CAS No.: 129567-00-6
• Molecular Formula: C₂₀H₃₄O₄Si
• Molecular Weight: 366.573

Synonyms:(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid

Chemical Property of (2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid

Chemical Property:

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Technology Process of (2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid

There total 1 articles about (2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one → (2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid (129567-00-6)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 1.5h;

DOI:10.1016/S0040-4039(00)88810-3

Reference yield:

(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid (129567-00-6) → (2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoyl chloride (129519-14-8)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; 5 deg C to room temperature;

DOI:10.1016/S0040-4039(00)88810-3

Reference yield:

(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid (129567-00-6) → 7-[(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,2-dimethyl-propionyloxy)-2-methyl-hexylidene]-2,3-diaza-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2 / DMF / benzene / 5 deg C to room temperature

3: 97 percent / CHCl₃ / 12 h / -4 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; benzene;

DOI:10.1016/S0040-4039(00)88810-3

Downstream raw materials:

(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoyl chloride

2,2-Dimethyl-propionic acid (2R,3S)-6-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-cyclopenta-2,4-dienylidene-2-methyl-hexyl ester

2,2-Dimethyl-propionic acid (3bS,4R,5S,7aR,8S,8aR)-8-(2-benzyloxy-acetyl)-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-2,4,5,6,7,7a,8,8a-octahydro-1H-cyclopenta[a]inden-3b-yl ester

2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

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