2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester
CAS No.:129436-67-5
Molecular Formula:C₃₃H₅₀N₂O₅Si
Molecular Weight:582.856
Hs Code.:

2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

There total 9 articles about 2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129519-14-8
(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoyl chloride

: 129436-67-5
2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

2: 97 percent / CHCl₃ / 12 h / -4 °C

3: 74 percent / H₂ / Pd(OH)2 / ethanol / 1.5 h / Ambient temperature

4: Zn(Cu) / methanol / 0 deg C to room temperature

5: 0.3M aq. K₃Fe(CN)6 / tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

6: 1) (COCl)2, DMSO 2) Et₃N / 1) CH₂Cl₂, 2h, -72 deg C 2) -72 deg C to room temperature

7: 1) NaN(TMS)2 / 1) THF, DMSO, 1.5h, 0 deg C

With zinc copper; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III); palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform;
DOI:10.1016/S0040-4039(00)88810-3

Reference yield:

: 129567-00-6
(2R,3S)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexanoic acid

: 129436-67-5
2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: (COCl)2 / DMF / benzene / 5 deg C to room temperature

3: 97 percent / CHCl₃ / 12 h / -4 °C

4: 74 percent / H₂ / Pd(OH)2 / ethanol / 1.5 h / Ambient temperature

5: Zn(Cu) / methanol / 0 deg C to room temperature

6: 0.3M aq. K₃Fe(CN)6 / tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

7: 1) (COCl)2, DMSO 2) Et₃N / 1) CH₂Cl₂, 2h, -72 deg C 2) -72 deg C to room temperature

8: 1) NaN(TMS)2 / 1) THF, DMSO, 1.5h, 0 deg C

With zinc copper; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III); palladium dihydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform; benzene;
DOI:10.1016/S0040-4039(00)88810-3

Reference yield:

: 129436-64-2
2,2-Dimethyl-propionic acid (2R,3S)-6-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-cyclopenta-2,4-dienylidene-2-methyl-hexyl ester

: 129436-67-5
2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / CHCl₃ / 12 h / -4 °C

2: 74 percent / H₂ / Pd(OH)2 / ethanol / 1.5 h / Ambient temperature

3: Zn(Cu) / methanol / 0 deg C to room temperature

4: 0.3M aq. K₃Fe(CN)6 / tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

5: 1) (COCl)2, DMSO 2) Et₃N / 1) CH₂Cl₂, 2h, -72 deg C 2) -72 deg C to room temperature

6: 1) NaN(TMS)2 / 1) THF, DMSO, 1.5h, 0 deg C

With zinc copper; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine; potassium hexacyanoferrate(III); palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform;
DOI:10.1016/S0040-4039(00)88810-3