Technology Process of (2R,4R)-benzyl 2-tert-butyl-5-oxo-4-((1-(triisopropylsilyl)-1H-indol-3-yl)methyl)oxazolidine-3-carboxylate
There total 5 articles about (2R,4R)-benzyl 2-tert-butyl-5-oxo-4-((1-(triisopropylsilyl)-1H-indol-3-yl)methyl)oxazolidine-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-2-amino-3-(1-(triisopropylsilyl)-1H-indol-3-yl)propanoic acid;
With
sodium hydroxide;
In
ethanol; water;
at 20 ℃;
for 1h;
Inert atmosphere;
t-butylglyoxal;
In
dichloromethane;
for 12h;
Inert atmosphere;
Molecular sieve;
Reflux;
benzyl chloroformate;
Further stages;
DOI:10.1021/jo302737j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: stannic tetrachloride pentahydrate / ethyl acetate / 48 h / 0 - 20 °C / Inert atmosphere
3.1: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C / Inert atmosphere
4.1: sodium hydroxide / water; ethanol / 1 h / 20 °C / Inert atmosphere
4.2: 12 h / Inert atmosphere; Molecular sieve; Reflux
With
stannic tetrachloride pentahydrate; potassium hexamethylsilazane; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1021/jo302737j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: stannic tetrachloride pentahydrate / ethyl acetate / 48 h / 0 - 20 °C / Inert atmosphere
3.1: lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C / Inert atmosphere
4.1: sodium hydroxide / water; ethanol / 1 h / 20 °C / Inert atmosphere
4.2: 12 h / Inert atmosphere; Molecular sieve; Reflux
With
stannic tetrachloride pentahydrate; potassium hexamethylsilazane; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1021/jo302737j
