3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

Base Information

Chemical Name:3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester
CAS No.:1572039-97-4
Molecular Formula:C₂₂H₂₁ClN₂O₂
Molecular Weight:380.874
Hs Code.:

Synonyms:3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

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Chemical Property of 3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

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Technology Process of 3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

There total 3 articles about 3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1572039-82-7
4-chloro-6-[(E)-3-phenylprop-1-en-1-yl]pyrimidine

: 4334-87-6
[3-(ethoxycarbonyl)phenyl]boronic acid

: 1572039-97-4
3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

Guidance literature:: With chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylic acid (2,4,6-triisopropylphenyl)amide; potassium hydroxide; In 1,4-dioxane; water; at 80 ℃; for 0.5h; enantioselective reaction; Inert atmosphere; Microwave irradiation;
DOI:10.1039/c4cc00340c

Reference yield:

: 10147-11-2
propargyl benzene

: 1572039-97-4
3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Schwartz's reagent; triethylamine / 15 h / 40 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / water; tetrahydrofuran / 16 h / Reflux

3: chlorobis(ethylene)rhodium(I) dimer; potassium hydroxide; (1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylic acid (2,4,6-triisopropylphenyl)amide / water; 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; Schwartz's reagent; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylic acid (2,4,6-triisopropylphenyl)amide; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1039/c4cc00340c

Reference yield:

: 177573-86-3
(E)-4,4,5,5-tetramethyl-2-(3-phenylprop-1-en-1-yl)-1,3,2-dioxaborolane

: 1572039-97-4
3-[(S)-1-benzyl-2-(6-chloropyrimidin-4-yl)ethyl]benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / water; tetrahydrofuran / 16 h / Reflux

2: chlorobis(ethylene)rhodium(I) dimer; potassium hydroxide; (1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylic acid (2,4,6-triisopropylphenyl)amide / water; 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylic acid (2,4,6-triisopropylphenyl)amide; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1039/c4cc00340c