2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine

Base Information

Chemical Name:2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine
CAS No.:116708-00-0
Molecular Formula:C₁₈H₂₇NO
Molecular Weight:273.418
Hs Code.:
DSSTox Substance ID:DTXSID101138225

Synonyms:DTXSID101138225;2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine;116708-00-0

Suppliers and Price of 2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:273.209264485
Heavy Atom Count:20
Complexity:354

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1(C(=C(CCN1C)C)C)CC2=CC=C(C=C2)OC

Technology Process of 2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine

There total 2 articles about 2-Ethyl-1,2,5,6-tetrahydro-2-[(4-methoxyphenyl)methyl]-1,3,4-trimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 38769-92-5
4-methoxybenzylmagnesium chloride

: 116708-10-2
2-cyano-2-ethyl-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine

: 116708-00-0
2-ethyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/S0040-4039(00)61840-3 DOI:10.1016/0223-5234(92)90150-Y

Reference yield:

: 73657-70-2
2-cyano-1,3,4-trimethyl-3-piperideine

: 116708-00-0
2-ethyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -40 deg C, 20 min, 2.) THF, from -40 deg C to RT, 30 min

2: 50 percent / tetrahydrofuran / 1 h / 0 °C

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/0223-5234(92)90150-Y