C₂₆H₂₃ClN₂O₇S

Base Information

• Chemical Name: C₂₆H₂₃ClN₂O₇S
• CAS No.: 1348182-69-3
• Molecular Formula: C₂₆H₂₃ClN₂O₇S
• Molecular Weight: 542.997
• Mol file: 1348182-69-3.mol

Synonyms:C₂₆H₂₃ClN₂O₇S

Chemical Property of C₂₆H₂₃ClN₂O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₃ClN₂O₇S

There total 5 articles about C₂₆H₂₃ClN₂O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl 1-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl malonate → C26H23ClN2O7S (1348182-69-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm500026w

Reference yield:

potassium 2-methoxy-4-nitrophenolate monohydrate (100200-99-5) → C26H23ClN2O7S (1348182-69-3)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium dihydrogenphosphate / water; acetonitrile / 3 h / 170 °C / 155149 Torr / Autoclave; Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

3: ethanol / 15 h / Reflux; Inert atmosphere

4: diisopropyl-carbodiimide; dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium dihydrogenphosphate; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; diisopropyl-carbodiimide; In ethanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm500026w

Reference yield:

1-(2-methoxy-4-nitrophenoxy)-2-methylpropan-2-ol (945720-36-5) → C26H23ClN2O7S (1348182-69-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr / Inert atmosphere

2: ethanol / 15 h / Reflux; Inert atmosphere

3: diisopropyl-carbodiimide; dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; diisopropyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm500026w

upstream raw materials:

potassium 2-methoxy-4-nitrophenolate monohydrate

1-(2-methoxy-4-nitrophenoxy)-2-methylpropan-2-ol

1-(2-methoxy-4-aminophenoxy)-2-methylpropan-2-ol

C₂₃H₂₁ClN₂O₄S