2-(2,2-difluorovinyl)-1,1'-biphenyl

Base Information

• Chemical Name: 2-(2,2-difluorovinyl)-1,1'-biphenyl
• CAS No.: 82979-53-1
• Molecular Formula: C₁₄H₁₀F₂
• Molecular Weight: 216.23
• Mol file: 82979-53-1.mol

Synonyms:2-(2,2-difluorovinyl)-1,1'-biphenyl

Chemical Property of 2-(2,2-difluorovinyl)-1,1'-biphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,2-difluorovinyl)-1,1'-biphenyl

There total 1 articles about 2-(2,2-difluorovinyl)-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + 2-Phenylbenzaldehyde (1203-68-5) → 2-(2,2-difluorovinyl)-1,1'-biphenyl (82979-53-1)

Guidance literature:

2-Phenylbenzaldehyde; With triphenylphosphine; potassium iodide; In acetonitrile; at 70 ℃; for 0.5h; Inert atmosphere;

2,2-difluoro-2-(fluorosulfonyl)acetate; In acetonitrile; at 70 ℃; for 3.16667h; Inert atmosphere;

DOI:10.1002/ejoc.201800468

Reference yield:

2-(2,2-difluorovinyl)-1,1'-biphenyl (82979-53-1) → 1-(biphenyl-2-yl)-1-(4,4'-difluorobiphenyl-2-yl)-2,2-difluoroethene

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / tetrachloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: lithium tert-butoxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane / tert-butyl alcohol; water / 6 h / 125 °C / Inert atmosphere; Schlenk technique

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; bromine; lithium tert-butoxide; In tetrachloromethane; water; tert-butyl alcohol; 2.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/acs.orglett.5b02426

Reference yield:

2-(2,2-difluorovinyl)-1,1'-biphenyl (82979-53-1) → 1-(biphenyl-2-yl)-1-(4,4'-dichlorobiphenyl-2-yl)-2,2-difluoroethene

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / tetrachloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: lithium tert-butoxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane / tert-butyl alcohol; water / 6 h / 125 °C / Inert atmosphere; Schlenk technique

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; bromine; lithium tert-butoxide; In tetrachloromethane; water; tert-butyl alcohol; 2.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/acs.orglett.5b02426

upstream raw materials:

2,2-difluoro-2-(fluorosulfonyl)acetate

2-Phenylbenzaldehyde