N-(2-fluorophenyl)-1H-imidazole-2-carboxamide

Base Information

Chemical Name:N-(2-fluorophenyl)-1H-imidazole-2-carboxamide
CAS No.:82173-01-1
Molecular Formula:C₁₀H₈FN₃O
Molecular Weight:205.191
Hs Code.:
European Community (EC) Number:659-214-3

Synonyms:N-(2-fluorophenyl)-1H-imidazole-2-carboxamide;82173-01-1;N-(2-Fluorophenyl)-1H-imidazol-2-carboxamide;SCHEMBL2817711;HRYSZBHYLUETBH-UHFFFAOYSA-N;AKOS023124076

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-fluorophenyl)-1H-imidazole-2-carboxamide

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:205.06514005
Heavy Atom Count:15
Complexity:237

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)NC(=O)C2=NC=CN2)F

Technology Process of N-(2-fluorophenyl)-1H-imidazole-2-carboxamide

There total 1 articles about N-(2-fluorophenyl)-1H-imidazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 348-54-9
2-Fluoroaniline

: 79711-73-2
diimidazo<3,2-a:3',2'-d>pyrazine-5,10-dione

: 82173-01-1
N-(2-Fluorophenyl)-1H-imidazol-2-carboxamide

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -10 - 20 ℃; for 4h;

Reference yield:

: 82173-01-1
N-(2-Fluorophenyl)-1H-imidazol-2-carboxamide

: 1-(3,4-dimethoxyphenyl)-N-methylimidazo[1,2-a]quinoxalin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl acetamide / 48 h / Reflux

2: N,N-diethylaniline; trichlorophosphate / 130 °C / Microwave irradiation

3: ethanol / 0.33 h / 150 °C / Microwave irradiation

4: N-Bromosuccinimide / chloroform / 1.5 h / Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 140 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; N,N-diethylaniline; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; chloroform; N,N-dimethyl acetamide; water; 5: |Suzuki-Miyaura Coupling;
DOI:10.1007/s10895-017-2097-z

Reference yield:

: 82173-01-1
N-(2-Fluorophenyl)-1H-imidazol-2-carboxamide

: 4-(4-(methylamino)imidazo[1,2-a]quinoxalin-1-yl)benzene-1,2-diol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl acetamide / 48 h / Reflux

2: N,N-diethylaniline; trichlorophosphate / 130 °C / Microwave irradiation

3: ethanol / 0.33 h / 150 °C / Microwave irradiation

4: N-Bromosuccinimide / chloroform / 1.5 h / Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 140 °C / Microwave irradiation

6: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium hydride; sodium carbonate; N,N-diethylaniline; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; water; 5: |Suzuki-Miyaura Coupling;
DOI:10.1007/s10895-017-2097-z