Imidazo[1,2-a]quinoxalin-4(5h)-one

Base Information

• Chemical Name: Imidazo[1,2-a]quinoxalin-4(5h)-one
• CAS No.: 133307-45-6
• Molecular Formula: C₁₀H₇N₃O
• Molecular Weight: 185.185
• ChEMBL ID: CHEMBL554030
• DSSTox Substance ID: DTXSID50576583
• Nikkaji Number: J424.714K
• Wikidata: Q82466366
• Mol file: 133307-45-6.mol

Synonyms:imidazo[1,2-a]quinoxalin-4(5h)-one;133307-45-6;5H-Imidazo[1,2-a]quinoxalin-4-one;Imidazo[1,2-a]quinoxalin-4(5H)-one (9CI);CHEMBL554030;4H,5H-IMIDAZO[1,2-A]QUINOXALIN-4-ONE;SCHEMBL2818529;DTXSID50576583;YTEOFXCKOQBQRA-UHFFFAOYSA-N;BDBM50007194;AKOS006273466;Imidazo[1,2-a]quinoxalin-4(5H)-one(9ci);EN300-196729;Z1198155664

Chemical Property of Imidazo[1,2-a]quinoxalin-4(5h)-one

Chemical Property:

• PSA: 50.16000
• LogP: 1.17580
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 185.058911855
• Heavy Atom Count: 14
• Complexity: 256

Purity/Quality:

95% ^*data from raw suppliers

Imidazo[1,2-a]quinoxalin-4(5H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)NC(=O)C3=NC=CN23

Technology Process of Imidazo[1,2-a]quinoxalin-4(5h)-one

There total 8 articles about Imidazo[1,2-a]quinoxalin-4(5h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(2-aminophenyl)imidazole (26286-54-4) + 1,1'-carbonyldiimidazole (530-62-1) → imidazo[1,2-a]quinoxaline-4-(5H)-one (133307-45-6)

Guidance literature:

In various solvent(s); for 1h; Heating;

DOI:10.1021/jm00113a002

Reference yield: 80.0%

N-(2-Fluorophenyl)-1H-imidazol-2-carboxamide (82173-01-1) → imidazo[1,2-a]quinoxaline-4-(5H)-one (133307-45-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; for 6h; Reflux;

DOI:10.1016/j.ejmech.2009.02.007

Reference yield: 54.0%

N-(2-iodophenyl)-1H-imidazole-2-carboxamide (1454816-05-7) → imidazo[1,2-a]quinoxaline-4-(5H)-one (133307-45-6)

Guidance literature:

With potassium phosphate; copper(l) iodide; tetrabutylammomium bromide; In water; at 120 ℃; for 8h; Green chemistry;

DOI:10.1016/j.tet.2013.07.036

upstream raw materials:

1-(2-aminophenyl)imidazole

1,1'-carbonyldiimidazole

2-chloro-3-(2,2-dimethoxyethylamino)quinoxaline

2,3-dichloroquinoxaline

Downstream raw materials:

N-methyl-1-phenylimidazo[1,2-a]quinoxalin-4-amine

EAPB₅₀₃

EAPB₆₀₃

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