2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

Base Information

Chemical Name:2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
CAS No.:1562526-18-4
Molecular Formula:C₁₁H₉F₂N₃O₃
Molecular Weight:269.208
Hs Code.:

Synonyms:2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

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Chemical Property of 2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

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Technology Process of 2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

There total 3 articles about 2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1562526-22-0
6-(benzyloxy)-4-(benzyloxymethyl)-2-(2,2-difluoro-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

: 1562526-18-4
2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; ethyl acetate; under 760.051 Torr;

Reference yield:

: 129973-51-9
2,2-difluoro-2-phenylethan-1-ol

: 1562526-18-4
2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 7 h / 0 - 66 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 2.08 h / 0 - 20 °C

3.1: hydrogen; acetic acid; palladium 10% on activated carbon / methanol; ethyl acetate / 760.05 Torr

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1562526-19-5
4-(benzyloxymethyl)-6-bromo-2-(2,2-difluoro-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

: 1562526-18-4
2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide

1.2: 2.08 h / 0 - 20 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / methanol; ethyl acetate / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide;