129973-51-9

Basic information

• Product Name: 2,2-Difluoro-2-phenyl-ethanol
• Synonyms: 2,2-Difluoro-2-phenyl-ethanol;β,β-difluoro- Benzeneethanol
• CAS NO: 129973-51-9
• Molecular Formula: C8H8F2O
• Molecular Weight: 158.148
• Mol File: 129973-51-9.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 2,2-Difluoro-2-phenyl-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Difluoro-2-phenyl-ethanol(129973-51-9)
• EPA Substance Registry System: 2,2-Difluoro-2-phenyl-ethanol(129973-51-9)

Safety Data

• Hazardous Substances Data: 129973-51-9(Hazardous Substances Data)

Usage

General Description

2,2-Difluoro-2-phenyl-ethanol, also known as DFPE, is a chemical compound with the molecular formula C8H8F2O. It is a fluoroalcohol with two fluorine atoms attached to a phenyl group. DFPE is commonly used as a reagent in organic synthesis and as a building block for the synthesis of pharmaceutical compounds. It is known for its role as a chiral auxiliary in asymmetric synthetic transformations. DFPE is also used in the production of perfumes and fragrances, and as a flavoring agent in food industry. It is important to handle DFPE with care, as it is considered to be toxic and may cause irritation upon contact with skin or eyes.

Upstream product

• 129973-38-2 2,2-Difluoro-2-phenylethyl phenyl sulfide 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 591-50-4 iodobenzene 
• 122-78-1 phenylacetaldehyde 
• 129660-35-1 α,α-difluoro-α-phenylacetaldehyde 
• 13344-76-8 α-fluorobenzeneacetaldehyde 
• 360-03-2 2,2-Difluoro-2-phenylacetic acid 
• 103-80-0 phenylacetyl chloride 
• 56071-96-6 methyl 2,2-difluoro-2-phenylacetate 
• 108661-89-8 2-Bromo-1,1-difluoro-1-phenylethane 
• 1786-36-3 (2-bromo-1-fluoroethyl)benzene 
• 696-31-1 α-fluorostyrene 
• 233280-91-6 2-acetoxy-1,1-difluoro-1-phenylethane 
• 129973-45-1 2,2-Difluoro-2-phenyl-1-(phenylthio)ethyl acetate 

Downstream Products

• 129660-35-1 α,α-difluoro-α-phenylacetaldehyde 
• 144156-71-8 Ethyl 3,3-difluoro-2-hydroxy-3-phenylpropanoate 
• 762292-90-0 2-amino-3,3-difluoro-3-phenylpropionic acid 
• 762292-95-5 3,3-difluoro-2-hydroxy-3-phenylpropionic acid 
• 144156-72-9 Ethyl 3,3-difluoro-2-oxo-3-phenylpropanoate 
• 144156-73-0 3,3-Difluoro-2-oxo-3-phenylpropanoic acid 
• 144156-69-4 3,3-Difluoro-2-hydroxy-3-phenylpropanenitrile 
• 915132-93-3 6-(2,2-difluoro-2-phenyl-ethoxy)hexan-1-amine 
• 838-41-5 2,4-diphenyl-1,3-oxazole 
• 20662-90-2 2-methyl-4-phenyloxazole 
• 915132-91-1 N-benzyl-6-(2,2-difluoro-(2-phenyl)ethoxy)hexane-1-amine 
• 1562526-22-0 6-(benzyloxy)-4-(benzyloxymethyl)-2-(2,2-difluoro-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 1562526-18-4 2-(2,2-difluoro-2-phenylethyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione 
• 1562526-19-5 4-(benzyloxymethyl)-6-bromo-2-(2,2-difluoro-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione 

Relevant articles and documents

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Lewis acid-mediated defluorinative [3+2] cycloaddition/aromatization cascade of 2,2-difluoroethanol systems with nitriles

The properties of C?F bonds, including high thermal and chemical stability, make derivatization of organic fluorine-containing compounds by the activation of the C?F bond and subsequent functionalization quite challenging. We herein report a Lewis acid-mediated defluorinative cycloaddition/aromatization cascade of 2,2-difluoroethanols with nitriles as a novel synthetic method for the preparation of 2,4,5-trisubstituted oxazoles. This reaction, which involves cleavage of two C?F bonds and the consecutive formation of C?O and C?N bonds in a one-pot fashion, features a broad substrate scope and moderate to high reaction yields. Mechanistic studies revealed that the reaction is initiated by the Lewis acid-mediated ring closure of the 2,2-difluoroethanol to produce the fluoroepoxide intermediate. (Figure presented.).