di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Base Information

Chemical Name:di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]
CAS No.:807341-89-5
Molecular Formula:C₄₄H₆₂N₄O₈
Molecular Weight:774.998
Hs Code.:

di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Synonyms:di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

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Chemical Property of di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

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Technology Process of di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

There total 6 articles about di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: benzyl {3-[3-(3-aminopropyl)-5-(hydroxymethyl)phenyl]propyl}carbamate hydrochloride

: 210355-26-3
3,5-Bis-(3-tert-butoxycarbonylamino-propyl)-benzoic acid

: 807341-89-5
di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Guidance literature:: 3,5-Bis-(3-tert-butoxycarbonylamino-propyl)-benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -30 ℃; for 3h;

benzyl {3-[3-(3-aminopropyl)-5-(hydroxymethyl)phenyl]propyl}carbamate hydrochloride; With triethylamine; In methanol; dichloromethane; at -20 - 20 ℃;
DOI:10.1002/hlca.200690246

Reference yield:

: 870177-64-3
ethyl 3-bromo-5-{3-{[(benzyloxy)carbonyl]amino}propyl}benzoate

: 807341-89-5
di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-BBN / toluene / 12 h / 20 °C

1.2: 86 percent / aq. KOH / Pd(PPh₃)4 / toluene / 14 h / 100 °C

2.1: 81 percent / LiAlH₄ / tetrahydrofuran / 8.5 h / cooling

3.1: 94 percent / aq. HCl / tetrahydrofuran / 0 - 20 °C

4.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / 3 h / -30 °C

4.2: 84 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; toluene; 1.2: Suzuki-Miyaura cross-coupling;
DOI:10.1002/hlca.200690246

Reference yield:

: 807341-84-0
benzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]dipropane-3,1-diyl}bis[carbamate]

: 807341-89-5
di(tert-butyl) {{5-{{{3-{3-{3-{[(benzyloxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / aq. HCl / tetrahydrofuran / 0 - 20 °C

2.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / 3 h / -30 °C

2.2: 84 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200690246