5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine
CAS No.:519056-26-9
Molecular Formula:C₃₃H₃₄N₂O₉
Molecular Weight:602.641
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

There total 8 articles about 5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 519056-25-8
5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 519056-26-9
5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

Guidance literature:: With pyridine; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2005.09.020

Reference yield:

: 519056-24-7
3'-O-benzyl-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

: 519056-26-9
5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

2: 100 percent / pyridine / 3 h / 20 °C

With pyridine; cyclohexene; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.bmc.2005.09.020

Reference yield:

: 583829-86-1
4-C-acetoxymethyl-1,2-di-O-acetyl-3-O-benzyl-5-O-tert-butyldiphenylsilyl-D-erythro-pentofuranose

: 519056-26-9
5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)uridine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / N,O-bis(trimethylsilyl)acetamide; TMSOTf / acetonitrile / 1 h / Heating

2: 90 percent / K₂CO₃ / methanol / 4 h / 20 °C

3: 81 percent / TsOH*H₂O / 1,2-dichloro-ethane / 3 h / Heating

4: 85 percent / TBAF / tetrahydrofuran / 4 h / 20 °C

5: 89 percent / cyclohexene / Pd/C / ethanol / 3 h / Heating

6: 100 percent / pyridine / 3 h / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane; acetonitrile; 1: Vorbrueggen reaction;
DOI:10.1016/j.bmc.2005.09.020