2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol

Base Information

• Chemical Name: 2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol
• CAS No.: 944835-69-2
• Molecular Formula: C₁₈H₉AsF₁₂O₂
• Molecular Weight: 560.171
• Mol file: 944835-69-2.mol

Synonyms:2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol

Chemical Property of 2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol

There total 1 articles about 2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol (718-64-9) → 2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol (944835-69-2) + 2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol

Guidance literature:

1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 8h; Inert atmosphere;

With arsenic trichloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/ic3014893

Reference yield: 20.0%

2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol (944835-69-2) + α-bromoacetophenone (70-11-1) → C26H15AsF12O3 (1243300-85-7)

Guidance literature:

2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol; With sodium hydride; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

α-bromoacetophenone; In acetonitrile; at 35 ℃; for 19h; Inert atmosphere;

DOI:10.1039/c0nj00035c

Reference yield:

2-[3,3-bis(trifluoromethyl)-2,1-benzoxarsol-1(3H)-yl]-α,α-bis-(trifluoromethyl)benzenemethanol (944835-69-2) → C32H21AsF12O3 (1243300-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

1.2: 19 h / 35 °C / Inert atmosphere

2.1: diethyl ether; cyclohexane / 2 h / -78 °C / Inert atmosphere

With sodium hydride; In diethyl ether; cyclohexane; acetonitrile;

DOI:10.1039/c0nj00035c

upstream raw materials:

1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol

Downstream raw materials:

C₃₂H₂₁AsF₁₂O₃

C₂₆H₁₅AsF₁₂O₃