4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1298101-54-8
Molecular Formula:C₃₂H₄₅N₅O₅Si
Molecular Weight:607.825
Hs Code.:

4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 9 articles about 4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1298101-53-7
4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-(S)-{[2-chloro-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1692-25-7
3-pyridylboronic acid

: 1298101-54-8
4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; at 130 ℃; for 0.5h; teflon-lined septum sealed Schlenk tube; irradiated in a microwave reactor;

Reference yield:

: 134441-71-7
(2S,4R)-1-boc-4-tert-butyldimethylsilylpyrrolidine-2-carbaldehyde

: 1298101-54-8
4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 1,2-dichloro-ethane / 1.5 h / 20 °C

1.2: 4 h / 20 °C

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water / 0.5 h / 130 °C / teflon-lined septum sealed Schlenk tube; irradiated in a microwave reactor

With potassium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; 1,2-dichloro-ethane;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1298101-54-8
4-(R)-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(4-methoxy-phenoxy)-2-(S)-(pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

3.2: -78 - 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 1.5 h / 20 °C

4.2: 4 h / 20 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water / 0.5 h / 130 °C / teflon-lined septum sealed Schlenk tube; irradiated in a microwave reactor

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; potassium carbonate; acetic acid; dimethyl sulfoxide; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;