(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

Base Information

Chemical Name:(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid
CAS No.:1402465-29-5
Molecular Formula:C₂₈H₂₆ClN₃O₄
Molecular Weight:503.985
Hs Code.:

Synonyms:(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

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Chemical Property of (R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

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Technology Process of (R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

There total 6 articles about (R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402466-07-2
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

: 1402465-29-5
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

Reference yield:

: 13524-04-4,131864-71-6,132437-66-2,120466-66-2
(R)-1-(o-chlorophenyl)ethanol

: 1402465-29-5
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane; toluene / 1 h / 0 - 20 °C / Molecular sieve 4?; Inert atmosphere; Reflux

1.2: 20 °C / Reflux

2.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C

5.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 0.5 h / 20 °C

With pyridine; tert.-butylnitrite; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; trifluoroacetic acid; copper(ll) bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1402465-77-3
(R)-1-(2-chlorophenyl)ethyl 4-bromo-1-methyl-1H-pyrazol-5-ylcarbamate

: 1402465-29-5
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

5: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 0.5 h / 20 °C

With tert.-butylnitrite; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; trifluoroacetic acid; copper(ll) bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;