(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

Base Information

Chemical Name:(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester
CAS No.:1402466-07-2
Molecular Formula:C₂₉H₂₈ClN₃O₄
Molecular Weight:518.012
Hs Code.:

Synonyms:(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

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Chemical Property of (R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

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Technology Process of (R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

There total 5 articles about (R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402466-52-7
(R)-1-(2-chlorophenyl)ethyl (4-(4-bromophenyl)-1-methyl-1H-pyrazol-5-yl)carbamate

: 490035-82-0
methyl 3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]propionoate

: 1402466-07-2
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 13524-04-4,131864-71-6,132437-66-2,120466-66-2
(R)-1-(o-chlorophenyl)ethanol

: 1402466-07-2
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane; toluene / 1 h / 0 - 20 °C / Molecular sieve 4?; Inert atmosphere; Reflux

1.2: 20 °C / Reflux

2.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C

5.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With pyridine; tert.-butylnitrite; sodium hydrogencarbonate; trifluoroacetic acid; copper(ll) bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1402465-77-3
(R)-1-(2-chlorophenyl)ethyl 4-bromo-1-methyl-1H-pyrazol-5-ylcarbamate

: 1402466-07-2
(R)-3-(4'-(5-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With tert.-butylnitrite; sodium hydrogencarbonate; trifluoroacetic acid; copper(ll) bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; acetonitrile;